In my previous blog we have looked at nano- and biosensor technologies that are opening new ways to diagnose and treat cancer. This blog deals with another fatal area – cardiovascular disease (CVD), the number one cause of death globally. An estimated 17.5 million people died from CVDs in 2012, representing 31% of all global deaths.

One of them was my friend. A sport fan, he was running, biking, regularly dropping into jims with all the nice gadgets around: Polar, Runtastic, you name it. Until one day he fell down from his treadmill, his heart stopped beating. He was always proud of his health, with no bad habits such as tobacco or alcohol consumption, saying nothing of addiction.

CVD cunningly disguises itself under treacherous symptoms such as pain in your arm(s), back, neck, jaw or stomach sickness (especially with women). Sometimes, we simply do not want to accept the fact that we are unconsciously trying to convince ourselves that unpleasant feelings we experience are attributed to a mere fatigue, nervousness of stress. Can technology, at least partially, assume the role of an unbiased judged? There are at least three important areas where it can:

Continuous monitoring with flexible sensor/patches

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Flexible skin patches, almost invisible on your body, are gradually surpassing wearable devices such as smart watches or bands providing high quality ECG measurements. A team of researchers of University of Illinois, Urbana-Champaign, have demonstrated the device that can be stuck to the skin to provide continuous ECG and EEG monitoring. The patch is wirelessly powered, sending and displaying data on an external device, e.g., a smartphone. When compared to commercially available ECG and EEG devices the patch “performed equally to conventional sensors, while being significantly more comfortable for patients.”

Thus Vital Connect debuted with VitalPatch biosensor that was presented at the 2016 Healthcare Information and Management Systems Society (HIMSS) conference and exhibition in Las Vegas.

This wireless, adhesive patch continuously monitors and records single-lead electrocardiogram (ECG), heart rate variability, respiratory rate, skin temperature, posture and fall detection with clinical accuracy. In case of suspicious deviations from the regularly heart performance the signal goes to the Vital Connect platform and is shared with the respective physician.

A professional 12–channel 24 hours (or more) ECG Holter device will soon be part of our standard dress code. Wearable garments such as Niturit, a seemingly ordinary T-shirt developed by the University of Aveiro in Portugal and the Israeli “Moked Enosh” company can record the heart activity transmitting it via a smart phone over a number of hours up to four consecutive days directly from a patient to a cardiologist. The T-shirt is being offered as part of examinations by the Moked Enosh center at the cost of $ 117.

 Nanosensors for preventive diagnostics

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Many hopes are associated with the development of nanosensors. Being attached to the molecular nanoparticles, such sensors are able to register the slightest alterations of a molecule’s spectrum instigated by the changed biochemical processes in the damaged cell. For example, this method can detect a heart attack by measuring stress symptoms in the heart.

The group of researchers from the Indian Institute of Technology , Mumbai, under Prof. V. Ramgopal Rao are developing a three-dimensional sensor system that measures the stress symptom (that can signify myocardial infarction) in the heart converting it into electrical signals. A severe stress prompts the excess of enzymes (protein or, rarely, RNA molecules that catalyze biochemical reactions) in the heart and the heart area, which may cause excessive pressure and exertion on blood vessels. When involved in a biochemical process with the enzymes, nanoparticle polymer generates the electric current which can be detected. The researchers are determined to produce a low cost system that will use molecular markers to predict and locate cardiac attacks, especially the fatal ones.

Scientists from the Massachusetts Institute of Technology and Harvard University are designing the system that can signal a heart attack by measuring the cumulative concentration of the respective biomarkers. The system consists of sensors housing iron oxide nanoparticles attached to antibodies of the protein in question. When target proteins go through the sensor membrane, nanoparticles are clinging to them, which alters the transverse relaxivity of surrounding water protons. This change in relaxivity can be read via magnetic resonance imaging (MRI) to quantify the concentration of biomarker over extended period of time. Scientists believe that the level of biomarkers’ concentration can help detecting cases of unrecognized MIs, which are accompanied by few or no symptoms and which, according to data from the Framingham Heart Study, constitute 28 percent and 35 percent of heart attacks in men and women, respectively.

One of the strongest proponents of the consumer oriented nanotechnology is Dr. Eric Topol, the chief academic officer in Scripps Health (San Diego). Together with his colleague Axel Scherer, PhD, of Caltech, Mr. Topol is designing tiny blood stream nanosensor chips that might spot predecessors of a heart attack. The sensors are picking up a specific genomic signal coming from endothelial cells that are sloughed off an artery wall in a precursory period before a heart attack. By transmitting the alert via smartphone to the cardiologist the myocardial infarction potentially can be prevented. When such technologies finally reach consumers, millions of unexpected heart arrests can potentially be avoided.

Heart on a Chip

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After the first experiment with cloning the sheep Dolly in 1996 many were dreaming: can we clone if not our whole body, but at least some of its vital organs? Would not it be nice getting a set of spare parts for a newly born just as spare parts are available for your new car?

Unfortunately, natural organs are reluctant to grow artificially. Human organs need a congenital medium to be connected to one another. For example, all the fancy collagens in the world can’t anchor a cell to a basement membrane that is not innate or induce the cell to reproduce in the lab environment while separated from other cells. But the dream is waiting for its proponents.

Professor Milica Radisic and the graduate student Boyang Zhang from U of T Engineering are among those researchers who attempted to grow human tissues in the lab. The result is AngioChip, a fully three-dimensional structure complete with internal blood vessels. For human cells to attach and grow around the chip, the researchers have built a scaffold out of POMaC polymer that is both biodegradable and biocompatible. The scaffold consists of several layers carved with a pattern of channels that are about 100 micrometers wide, the diameter of a human hair. The layers are covered with the 3D structure of synthetic blood vessels. The UV light is cross-linking the polymer bonding it to the layer below. The whole structure is then immersed into a liquid containing living cells. The cells quickly attach to the inside and outside of the channels and start growing just as they would in the human body.

The team is currently building models for heart and liver that function as the real ones. For example, liver, according to the researchers, can produced urea and metabolized drugs. The blood vessels of the two artificial organs could be connected, thereby modelling not just the organs themselves, but the interactions between them. So far, such “organ on a chip” is designed for testing new drugs, but the researchers believe that it could eventually be used to repair or replace damaged organs.

If flexible patches and biosensors may finally reach the consumers within the foreseeable future, it is still hard to imagine that we will receive a key from a locker stuffed with our human spear parts. But the studies are definitely going into this direction. As patients we are used to be patient. We will wait.

Anywhere, from 15% to 28% of cancer diagnoses are misleading. This was the alarming conclusion of an Exploring Diagnostic Accuracy in Cancer survey conducted at late 2012 by the US National Coalition of Health Care and Best Doctors .

The traditional methods of cancer diagnostics such as, e.g., mammography (for breast cancer), CT scans, X-ray, ultrasound imaging, MRI and PET (for various other types of cancer) or endoscopy, followed by biopsy of suspicious tissue (in case of gastrological cancer) could be traumatic and still are not 100% reliable. The US National Cancer Institute study revealed that of all breast cancer cases detected by screening the mammograms, up to 54% are estimated to be the result of overdiagnostics. Overdiagnosis can expose a woman to such risks as surgical deformity or toxicities from radiation therapy, hormone therapy or chemotherapy and late effects of therapeutic radiation (new cancers, scarring, or cardiac toxicity).

Obviously, new methods of precise and early cancer diagnostics and treatment without exposing patients to the danger of radiation, chemotherapy or surgical interventions are badly required. The evolution of nanotechnologies is promising to generate ones.

Nanoparticles, those tiny functional systems less than 100 nanometers, were first envisioned as early as in 1959 by the famous US physicist Richard Feynman. Encapsulated into biosensors (nanotubes, smart pills or patches) implanted into the human body, nanoparticles are able to “recognize” the so called “biomarkers”, those early indicators of the diseased cells, such as fragments of a protein, DNA or RNA-based. Upon receiving biological signals produced by damaged cells (e.g. fluorescent, heat, oxygen or other manifestations of metabolic changes associated with a disease) these sensors can transmit information wirelessly to respective physicians.

Thus, the researchers from the Massachusetts Institute of Technology (MIT) have designed a carbon nanotube sensor that can be implanted under the skin for over 1 year to detect a molecule of nitric oxide (NO), a signaling molecule within living cells that carries messages between the brain and immune system functions. In case of cancerous cells, the ordinary levels of NO are disturbed.

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Carbon nanotubes can have a natural fluorescence, and when they attach themselves to a certain target, brighten or dim. Short term nanosensors are injected into the blood stream and when injectable on mice are passing through the lungs and heart or gather in the liver, without causing damage on the way. Once in the liver, the sensors are able to monitor NO. The other sensor is covered by alginate gel and implanted under the skin for a period of 400 days or potentially even longer. When both sensors are in the body, they produce a near-infrared fluorescent signal by shining a tiny laser on them. This information is then passed to an instrument that detects the difference between the nanotubes and other areas that may give off fluorescence.

Millions of women are taking annual mammogram screening for a fear of breast cancer. During the procedure the breast tissue is squeezed firmly between two plates. This is not only painful, but can damage small blood vessels resulting in existing cancerous cells spreading to other areas of the body.

To make breast cancer test easier Reno, a Nevada-based company, has designed a wearable sensor that could be inserted into the women’s bra. The sensor detects tiny metabolic temperature changes caused by cancerous cells in a tumor. The temperature readings are sent back to a global library where they’re run through a proprietary algorithm. A woman can wear the garment for a few hours, and the information will be automatically communicated to her physician. Researchers claim that the breast sensor bra may work even better than a mammogram for patients in the early stages of cancer or with dense breast tissue, a condition affecting over half of all women.

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El Camino Hospital in Bay Area is currently running clinical trials with Cyrcadia Health iTBra. A tiny patch inserted in the bra tracks temperature changes within two hours sending information to a physician via a smart phone. Women can perform breast cancer diagnostics in their home not being subjected to an unpleasant mammogram test. If trials proved to be successful the Cyrcadia Health hopes to have the iTBra on the market later this year.

Blood test can already alert us on many potential disorder such as liver damages with Aspartate aminotransferase (AST) or Alanine aminotransferase (ALT) enzyme concentration analysis or creatinine level to spot kidney disorders. Why not cancer? Unfortunately due to the impact of multiple ingredients contained in the blood such as proteins and ions, the detection of a specific cancer biomarkers is not easy. Usually such analysis are carried in the controlled laboratory environments.

BloodBiomarkerThe first attempt to detect cancer biomarkers in the whole blood was done by the team led by Mark Reed, Yale’s Harold Hodgkinson Professor of Engineering & Applied Science, and Tarek Fahmy, an associate professor of biomedical and chemical engineering. The researchers used nanowire sensors to measure concentrations of two specific biomarkers: antigens specific to prostate and breast cancer. The sensor works as a filter: catching the biomarkers on a chip while washing away the rest of the blood.

With this method researchers are able to detect extremely small concentration of antigens at the range of picograms per milliliter, equivalent to something like a single grain of salt dissolved in a large swimming pool. Should such methods be successful, we would be able in the near future to receive a preliminary alert of oncological disorders by a familiar blood test.

Nanosensors may allow not only to detect, but to treat the disease. Researchers from the Tel Aviv University under supervision of Prof. Dan Peer invented a novel method of treating aggressive forms of blood cancer such as Mantle Cell Lymphoma (MCL). The researchers noticed that MCL is associated with the intensified activity of a certain gene, namely the gene CCND1. When over-expressed, the CCND1 gene produces too much of a Cyclin D1 protein, sometimes 3,000 – 15,000 times too many. To reduce and regulate protein production the scientists have invented the CCND1 blocker: the synthetic strand of RNA molecules (siRNA). By targeting RNA molecules that convey genetic information from the DNA to the ribosomes, the inner-cell structures where new protein chain are assembled (translated) from amino acids, siRNA disables its ability to express a specific gene. To deliver siRNA precisely to CCMD1 gene, it is loaded into the lipid-based nanoparticles (LNPs) coated with antibodies. Scientists believe that such method could be applied not only for MCL but also for other malicious forms of cancer. The results of the study were published in the journal Proceedings of the National Academy of Sciences of the USA.

Another form of cancer that is developing almost unnoticeably is a lung cancer. Traditional methods to diagnose lung cancer such as bronchoscopies, computer-guided biopsies or surgery are invasive and may cause additional harm to patients. Breath analyzers provide a method of detecting lung and other form of cancer (e.g., gastroenterological types of cancer) by simply “sniffing” cancer in the breath. Coated with tiny nanowires, these sensors can identify miniscule amounts of chemical compounds exhaled with the breath thus measuring the concentration of cancer biomarkers contained in those components.

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The Israel Institute of Technology of researchers under Prof. Hossam Haick can analyze more than 1,000 different gases contained in the breath that may indicate various illnesses. For example, by analyzing the concentrations of eight specific substances (out of 130) in the oral cavity, the technology allowed the researchers to distinguish between the patients suffering from gastric cancer and the healthy individuals with 92% accuracy.

Will such technologies finally reach people who are anxiously waiting for more reliable and accessible methods of cancer diagnostics and treatment? The success and acceptance of such methods depend on manifold skills of computer scientists, biochemical engineers, physicist, biologists and physicians thus requiring tight cooperation across multiple professional organizations. When such cooperation has been achieved, it can lead to stunning discoveries that potentially will save millions of lives.

 

 

 

 

 

 

Considering the amount of medications each of us is swallowing during the lifecycle, one would assume that the pharma industry is tremendously flourishing. Indeed, the total volume of the pharmaceutical market was in 2014 worth of 1,057.2 Billion dollars, with the top 15 companies reaching around US$527 billion in revenue. Nevertheless, the modest year-on-year 2.4% growth indicates that the industry needs some revitalizing changes.

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One of the biggest challenges pharma is facing are consumers. Almost 50% of patients who are stubbornly refusing to take medications are accountable for approximately $100 billion per year loss to pharma companies, according to the Mayo clinic proceedings.

It is hard to imagine that a person is persistently forgetting to take a medication that presumably brings a relief. Often the reason is not negligence, but fear. Fear to take medications that instead of healing can produce adverse effects. The National Council for Patient Information and Education reported that in the US alone adverse drug effects have been blamed for 125,000 deaths annually. According to American Society of Consultant Pharmacies (ASCP), medication-related problems cost the industry $177.4 billion a year, more than all possible losses related to nonadherence.

Reputation is another challenge pharma industry has to confront with. The results of clinical trials are no longer an exclusive property of pharmaceutical companies. More and more opportunities are available to consumers to share their experiences via social networks such as Facebook or Twitter. The Patient Safety Journal published a study collected from more than 1,000 public tweets in English containing key phrases such as “doctor screwed up”. Eighty-three percent of the tweets, posted between January and August 2012, specified that 23 percent of all errors concerned medications, 23 percent involved diagnostic mistakes and 14 percent involved surgical errors.

Pharmaceutical industry has to cope with the openness and transparency of the digital environment. But this challenging environment can also open new opportunities. There are at least three areas for digital technologies to drive value to pharma industry and patients.

1. Improvement of clinical trials with advanced analytical and cloud computing.

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 Clinical trials are not only expensive with the average cost per patient increasing from 2008 to 2013 by $23,600, or 157%, but they can be also dangerous. The media reported recently that in France one person has been left “brain-dead” and five more hospitalized after a clinical trial on an experimental drug went wrong.

Moreover the majority of clinical tests are based on the erroneous statistical principle “should work at average”. But outside of clinical laboratories such “average patient” does not exist. Each person has a specific reaction on medications depending on multiple factors such as age, gender or life style. The results of clinical tests do not answer the main question: should such medication work for you.

Discoveries in pharmacogenomics make it possible to adjust medication treatment to an individual by analyzing her/his genetic profile. A number of commercial companies are stepping into the market to assist consumers in deciphering their genomic code. Thus Navigenics (Life Technologies) is testing 12 drugs including response to beta blockers, while HealthspecPGT is promising customers 250 medications test including antidepressants, pain killers, hypertension drugs, statins and anticoagulants such as warfarin. If pharma companies get an access to anonymous results of personal genomic tests (and we leave aside for a moment privacy requirements and concerns) they can, e.g., identify and flock together similar genomic patterns to produce medications that can precisely target a specific group of individuals suffering from similar diseases.

But to store for decades and dig into myriads of personal genomic data consume a lot of resources. Cloud computing allows researchers to access and analyze almost unlimited amount of records collected from a variety of mobile and wearable devices, personal and medical health records as well as social networks. Thus, the team of the Virginia Tech researchers under supervision of a Professor Wu Feng, have “cloudified” their preexisting Genome Analysis Toolkit using the computing infrastructure of Microsoft’s Hadoop-based Azure HDInsight Service. The new version called SeqInCloud (as in “Sequencing in the Cloud”) can take minutes to sequence and analyze a genomic data set, while previously it used to take two weeks. According to Feng “rather than relying only on the wet- lab to make their discoveries, we are able to use validated computational models to simulate wet-lab processes in a fraction of the time.”

Feng’s team receives thousands of requests a year from all over the world from biologists, microbiologists, epidemiologists, and others who don’t have the computational resources or expertise to process the massive amount of data available in the field of genomics. Similar tools and services could certainly benefit pharma to carry clinical trials cheaper and faster producing medications that can help real people vs. statistical objects.

2. Development of biosensors and smart pills.
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Drugs equipped with nanosensors that check individual reaction on the consumed chemical substances are knocking at the doors of pharmaceutical companies. Proteus smart pills monitors patient’s heart rate, respiration and temperature providing evidence on individual response to medication digestion. Gastroenterologists at the University of Chicago Medicine are experimenting with an electronic “smart pill” that takes measurements of temperature, pressure and pH inside the digestive tract to monitor medication’s consumption. HQ Inc’s CorTemp Ingestible Body Temperature Sensor pill is capable of transmitting temperature to a smartphone app in real time as it travels through the body.

However, the majority of such pills are tracking manifestations of the body’s physical conditions. But researchers are digging deeper. A team from the Moscow Institute of Physics and Technology (MIPT) has patented a biosensor chip based on graphene, graphene oxide and carbon nanotubes that will analyze biochemical process of the human organism under the impact of medications. These sensors enable researchers to detect low concentrations of biologically significant molecular substances (RNA, DNA, proteins, antibodies and antigens, viruses and bacteria) and to study their chemical properties under the impact of consumed substances. The data obtained gives information about the efficacy of a drug and its toxicity in case it targets “healthy” cells or their parts, which the drug, ideally, should not affect.

In future your mobile phone will be sending you a message informing that the dosage of medication you have just swallowed should be reduced or totally abandoned, based on your biochemistry and genetic profile.

3.Integration into continuous healthcare.
Medication therapy plays an important role in the clinical process, hence pharma industries should naturally share its ultimate goal and responsibility. This implies that the measurement of the pharma success should depend not only on the number of pills developed and sold or prescriptions written, but rather on how many of those medications improved patient’s health. To achieve this goal pharma companies have to collaborate intensively with health providers, patients and payers, with this collaboration not being reduced to the intention of selling their products against those of competitors.

Collaboration also means to “open up” for instant health information exchange with hospitals, homecare nurses, patients and physicians in order to collect and analyze impacts of medications on millions of people. Powerful and secure IT platforms are required to realize this vision.

IT vendors such as Microsoft, Apple or IBM are accumulating tons of patient’s records collected from wearable devices and mobile applications on platforms such as Microsoft Health, Health Vault or Apple Research Kit. Technologies such as Skype or Skype for Business are providing a space for ­clinicians to connect with each other via ­messaging, voice, and video ­conferencing from multiple devices. This process is naturally manifested in socium: for instance, political parties in the United Kingdom are promising to enable patients to use Skype for calling general practitioners by 2020.

Despite all the concerns about privacy and security, many patients are willingly sharing their health data with a hope to receive better care if not for themselves but at least for those who may be confronted with similar diseases. Social networks such as PatientsLikeMe or ProPublica are engaging people to provide feedbacks on therapies they are receiving.

By establishing the right partnership with IT and bioinformatics technology providers, pharmaceutical companies will be able to develop a more personalized and precise medications which finally will improve drug adherence as well as the overall health outcome.

End of the year is the time to contemplate on significant achievements of the past. Cleveland Clinic is releasing the list of top medical innovations 2015 naming telestroke units as number one achievement; ReferralMD are coming with their view on 10 Biggest Innovations in Health Care Technology in 2015 which includes blood nanobotos and almost fantastic Head Transplants and Mind Transfer project, the computerized scanned copies of our brain.

But what are the most important technologies that will help people to better manage their health? From this perspective, here are my top favorites: a) wearables for continuous monitoring of life-threatening conditions (such as cardio failure or stroke); b) nano/bio sensors for predictive and non-invasive diagnostics; c) technologies for personalized medications that will be helpful and not harmful. Please share your views.

  1. Wearables for continuous health monitoring.

Personal wearables allowed people to actively participate in clinical decisions by getting a better insight into their health. Multilayered sensors can scan your body measuring vital parameters such as temperature, perspiration, electrical conductivity of the skin, electric field distribution around the body that, if properly interpreted, can indicate early deviations from individual homeostasis.

Let us take cardio failure. According to Heart.org cardiovascular disease is the leading global cause of death, accounting for 17.3 million deaths per year, a number that is expected to grow to more than 23.6 million by 2030. Instead of checking ECG sporadically during doctor’s visits, people will be able to constantly monitor their heart activity alerting, if needed, a cardiologist of a potential threat.

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Wearable garments such as Niturit, a seemingly ordinary T-shirt developed by the University of Aveiro in Portugal and the Israeli “Moked Enosh” center, was chosen by the European Space Agency to check cardio conditions of  astronauts. With the help of embedded electrodes this T-shirt can record heart activity transmitting it via a smart phone over a number of hours up to four consecutive days directly from a patient to a cardiologist. The examination captures irregularities in heart rate and other disorders that may point to sudden arterial blockages. The T-shirt is being offered as part of examinations by the Moked Enosh center at the cost of $ 117.

QardioCore is another example. This three-channel EKG/ECG monitor can continuously record your electrocardiogram, heart rate variability, body temperature, respiratory rate and galvanic skin response. Bluetooth enabled and connected to the Cloud-based system via a mobile, this device allows doctors to get a real time picture of your heart health without the hassle of gels and patches. HealthWatch is one more variation of a smart T-shirt that has increased its capacities up to 15-lead ECG-sensing. This smart garment can read heart rate, blood pressure, detect cardiac irregularities and other vital signs to prevent sudden heart attacks. Maybe one day smart garments transformed by Ralph Lauren, Diesel and Guess into a truly desirable dresses will become part of our wardrobe?

Arterial hypertension is another area that technology should be addressing urgently. More than a billion people are measuring their blood pressure (BP) daily in order to avoid the possible consequences of hypertension. Elegant wrist bands and watches are attempted to substitute standard clumsy BP devices. But accuracy is still a problem: the arteries at the wrist are narrower and lie not so deep, so to obtain an accurate measurement from wrist bands and watches is more difficult. Wrist devices are also sensitive to muscle contractions that can uncontrollably increase or decrease the pressure readings displayed by the device.

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Nevertheless, the researchers are not giving up.  Scientists from the University of Leicester came with the idea to measure BP directly in the aorta, a so called ‘central aortic systolic pressure’ or CASP. To monitor the aorta BP can be especially important since it is close to the heart, precisely the area where the high blood pressure can cause most damages. Normally, the aorta BP was measured through surgical procedures, since it is hard to reach its location. The scientists from the University of Leicester together with the Singapore-based medical device company HealthSTATS International took an innovative approach. Their sensors are recording the pulse wave. By establishing through multiple tests the correlations between the pulse wave and CASP, they have developed a computerized mathematical algorithms that recalculate pulse wave data into CASP with a 99% correlation.

STBL Medical Research AG (STBL), a Swiss company, and the Swiss Federal Laboratories for Materials Science and Technology (EMPA) came with another version of a comfortable wrist watch device. The sensors embedded into the device simultaneously record contact pressure, pulse and blood flow on the skin surface near the wrist. Since the pressure of the device on the skin is constantly changing, with the characteristic period that is typically less than the reaction time of the device, the accuracy of the measurements was initially rather low. To overcome this issue the EMPA engineers developed a sensor made from piezo-resistive fibers. The electrically conductive fibre detects any movement and change in pressure and rapidly converts such changes into electrical signals transmitting data to the measuring device, thus eliminating the noise from a desired signal. If these devices finally reach consumers they can probably save millions from detrimental consequences of hypertension.

  1. Sensors for preventive care

According to a panel of the independent Institute of Medicine, the health arm of the US National Academy of Sciences, nearly 600,000 people — 1,600 a day — suffer from sudden heart stoppages every year, about 400,000 of them outside hospitals.

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New wave of nanosensors such as tiny blood stream chips designed by Scripps Health (San Diego) can assist in early detection and ultimate prevention of a cardio arrest. In the precursor period before a heart attack the endothelial cells that line the interior surface of blood and lymphatic vessels, are sloughed off an artery producing a specific genomic signal. By picking up this signals, sensors may spot predecessor of a heart attack and alert cardiologists via a smart phone.

HealthPatchMD is a reusable biosensor embedded in a disposable patch. With ECG electrodes, 3-axis MEMS accelerometer and thermistor for skin temperature detection, this device is tracking a single-lead ECG, heart rate, breathing, temperature, steps, and even body position in case of a fall. The data picked up by a biosensor are transmitted via Bluetooth to any mobile device in the real time. The product has received FDA clearance for sale in the US, regulatory approval (CE Mark) for distribution in EU, got Ninsho certification in Japan and is registered for distribution in Canada.

Neurological disorders is another area where sensors can provide rapid and non-invasive diagnostics. EIMindA , an innovative start up from Israel has attracted investors with their elegant helmet containing dozens of electrodes that measure electronic activity of the brain at different points through the skull. Each sensor is recording the activity associated with a specific brain function – thought, memory, activity, etc. detecting and eliminating the “noise”, produced other electrical activities of the brain. The technology will allow physicians to monitor and manage patient’s brain functioning throughout the course of life and diagnose brain injuries such as concussion or potential threat of Parkinson or Alzheimer

3.“Breathtaking” non-invasive diagnostics

Breathanalyzers, formerly used merely for alcohol and drug tests, in future will allow detecting various pathologies reporting data directly to laboratories. Coated with tiny nanowires, these sensors can “sniff” miniscule amounts of chemical compounds exhaled with the breath and identify biomarkers contained in those components. This will help physicians to recognize a vast spectrum of metabolic dysfunction such as diabetes, lung or gastro cancer.

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Ronnie Priefer, Ph.D., a Professor of Medical Chemistry at WNE in Springfield, Massachusetts has developed a non-invasive wearable glucose monitoring device that reports data to physicians and clinical laboratories in the real time. The scientists used nanometer-thick films consisting of two polymers that react with acetone, the organic compound that indicates diabetes and is exhaled with the breath. By interacting with polymers, the acetone alters the chemical nature of the film. The film discloses the detected amount of acetone, which points on the level of glucose in the blood. Given that 10% of the world’s adult population according to WHO are suffering from diabetes, the demand for non-invasive breath analyzers predicted to be huge.

Gastroenterological disorders is another area where breath sensors can be highly required. The initial stage of the gastric or esophagus cancer are often hard to detect as there are typically no distinct symptoms. A patient suspected with gastrointestinal cancer has to go through endoscopy, followed by biopsy of suspicious tissue.  Breathanayzers can detect complex forms of cancer on an early stage without subjecting patients to complex and risky clinical tests. According to the British Journal of Surgery report, the breath test could identify the cancer patients (some of whom had colon cancer) at 76%. And earlier this year, an Israeli study of 74 patients proved that a breath test could correctly tell malignant lung tumors from benign ones in 90% of the time.

Commercial versions of breathanalyzers are already entering the market.  Na nose, created in Technion – the Israel Institute of Technology by the team of researchers under Prof. Hossam Haick can analyze more than 1,000 different gases contained in the breath that may indicate various illnesses. For example, by analyzing the concentrations of eight specific substances (out of 130) in the oral cavity, the technology allowed the researchers to distinguish between patients with gastric cancer and healthy individuals with 92% accuracy.

4.Personalized medication trackers

Medication adherence is a nightmare both for patients and clinicians. Almost 50% of patients are not taking their medications as prescribed by their doctors. According to the Mayo clinic proceedings  the poor adherence to medication incur costs of approximately $100 billion per year”. But the costs of medication damages are even more. According to American Society of Consultant Pharmacies (ASCF), medication-related problems cost $177.4 billion a year. The majority of clinical tests are based on the statistical principle “should work at average”. But each person has a specific metabolic system and hence different reaction on medications depending on multiple factors such as age, gender and life style. The results of clinical tests do not answer the main question: should such medication work for you.

Pharmagenomics promises that medication treatments can finally be tailored to individuals. By taking a sample of your tissues and deciphering your genome, doctors will be able to prescribe medication and dosage precisely for you achieving a successful treatment, while avoiding harmful side effects.

Although the research is still on the initial stage, commercial companies are already entering “direct-to-consumer” genetic tests market. Navigenics (acquired by Life Technologies) is testing 12 drugs including response to beta blockers, while HealthspecPGT is promising its customers 250 medications test including antidepressants, pain killers, hypertension drugs, statins and warfarin.

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The predictions hold that by 2020 the amount of genomic data will exceed that of YouTube, with genomic computations exceeding 5 million computer days per year. To analyze, store and distribute genomic data without powerful IT tools and special analytical platforms will be inconceivable. This novel IT technology will create new opportunities not only for professional ICT companies, but also for some healthcare organizations with large ICT departments. Thus Partners Healthcare is coming up with GeneInsight, a sophisticated computer program able to crash mountains of patient’s data to identify the genetic factors contributing to heart conditions. The company is now promoting the SW to other hospitals on a royalty bases.

Genelex, a Seattle based company, is offering YouScript, a medication analytics tool used by doctors to guide genetic testing and improve drug treatments. This decision support system has already helped hospitals to decrease emergency visits in elderly patients by 71%, and hospitalizations by 39%.

Identification of people with similar genomic structure is a global task involving pharma experts, bioinformatics, and physicians all over the world. Cloud computing  will be extensively used to store and distribute patient’s genomic data by multiple stakeholders. But sensitivity of such a data will require an enhanced security. Not every hospital or lab will have the capacity to invest heavily into the trusted cloud infrastructure. The solutions  addressing security issues are coming to the market. Microsoft is bringing SEAL, Simple Encrypted Arithmetic Library, a free tool for biomedical data processing and encryption. The encryption is based on homomorphic method that encodes data in such a way that they could be stored in the untrusted Cloud environment, while still being protected. Healthcare organizations will be able to outsource patient’s biosamples to, e.g., specialized bioinformatics companies for genomic analysis and continue working on the data on their premises without compromising the security.

Maybe in the future consumers will be receiving medical prescriptions based on their DNA and RNA variations directly via their mobile applications?

What are your top favorite innovations that will help consumers to support their health?

 

Powerful analytical engines are ready to mine terabytes of patients’ data collected from watches, bands or implanted sensors. Major IT vendors are offering providers their platforms such as Microsoft Health, Apple Health Kit or IBM Watson for a better insight into patients’ health conditions. Powerful pharmaceutical industries are looking at Apple ResearchKit to collect anonymous health data from a vast majority of iPhone users. Similar initiatives are driven through social networks such as PatientsLikeMe, encouraging members to share their health data with research and pharmaceutical industries.

BIgDataPatientsExpectations are that the pool of Health-related BIG DATA, when crunched and analyzed, will facilitate a more precise diagnostics, better medication treatments and finally will improve healthcare processes. Consequently, in due time each individual will receive its share of benefits. But no expert is able to promise when those advantages would reach personally you.

Meanwhile millions of individuals are monitoring daily their vital signs such as blood glucose level, heart rate and medications with only one selfish hope: improve their own health and as soon as possible. Alas,  even those  observations one regularly collects still do not suggest how to make personal health results look better. Should I, e.g., increase my beta-blocker from 0.5 to 10.0 mg, switch to another drug or simply move to the country where the climate is better for me?

To interpret health data correctly people need to understand the dependencies between their personal health parameters (e.g., blood pressure) and external factors that can affect them, e.g., medications, stress, weather, physical activities, etc. In short: for consumer health applications to be demanded, health analytics for person’s “small data” is strongly required.

Unfortunately the majority of developers are still reluctant to add analytical engines to personal health tracking tools. Numerous mobile apps appearing on the market targeting diabetes, hypertension or cardio disorders are still presenting user silos of health-related data.

Let’s take hypertension. Over a billion people are measuring their blood pressure daily in order to avoid the possible consequences of this condition. As a user I was keen to test some of the top blood pressure application available for Android, Apple and Windows. The criteria were: rating, mobility, ease of use. Since the first time users are normally not ready to pay for something they have not checked before, mainly the for free applications were randomly considered.

Although different in colors and layouts, the reviewed apps were mainly offering the same familiar functionalities with similar data sets such as systolic, diastolic, pulse rate, weight and BMI. Additional options ( meant more for physicians rather than  for consumers) were left/right hand measurements, position (seated, laying). Some apps such as iBP Blood pressure additionally contain the glucose level. The promised correlations offered by charts simply show different data (the blood pressure measurements, weight and glucose levels) presented on a single page.

iBP blood pressure

The Blood Pressure Monitor – Family Lite by Taconic System LLC is seemingly more advanced promising consumers “lifetime data visualization, statistics reporting, medication correlation, email import/export, built-in reminders and much more”. Nevertheless, despite its multiple configurable pages including medications inputs and additional services such as “built-in reminders”, it basically shows static pages and not a dynamic analysis.

BloodPressureFamiliyLite

Among the “rising stars in blood pressure apps” one can find fingerprint blood pressure pranks that scan your blood pressure when you are pressing your finger to the designated area on the phone.

BloodPressureFinger

Numerous apps of this category such as the one designed by Prixlogic or Finger Blood Pressure by Onex Softech are more like an idea than a real BP app. One can only guess how these apps are supposed to operate and what exactly they measure.  No surprise when you see the difference in results in systolic something about 20-30 mm Hg or even more compared to the numbers obtained from standard medical BP devices.

The Instant Blood Pressure app allegedly designed by respectable experts from John Hopkins “promises to measure your blood pressure using just your iPhone” has also received mixed feedbacks. The app claims to use the iPhone sensors to measure blood pressure without using a blood pressure cuff.  It asks you to place your finger on the camera (measuring your heart rate), and place your phone’s microphone on your heart. The measurements were not really tested and were giving unreliable results. For example, a person had 170 systolic, while the reading indicated a normal BP. Finally, the University had to send to “the app’s maker, Aura Labs, a cease-and-desist letter demanding that they stop using their name”.

Although the simplicity of the usage is tempting, so far mobile BP measurement apps are in no way a substitution to the standard medical devices. The accuracy of measurements is, as a rule, totally inadequate.

To design a meaningful healthcare application for consumers, developers have to step into their shoes. To work with medical professionals is absolutely necessary, but not enough. One has to “feel with his own skin” what the priorities are for people, and what is excessive, unnecessary and can wait. Patients simple do not have neither time nor capacity to input and track abundance of parameters. However, there are ones such as the medication intake, which are absolutely key. By simply including a medication field and presenting the user with a visual chart that shows the dynamical dependencies between the drug dose and physiological parameters an individual is tracking, will help a person to understand her/his conditions better and tune the treatments. Consequently, the utilization of such applications will increase. The parameters can of course vary depending on physical disorders. For example, people with cardio -vascular problems are often meteo-dependent.  The weather  for them can become an important factor. So why not to integrate blood pressure apps with the numerous existing weather forecast applications?

I hope that developers will finally pay attention to individuals’ “small data” by adding  extensive analytics as a standard function to personal  health applications. Until that happens I will continue using my modest blood pressure tracker on my Windows Phone, guessing helplessly what is more important for my results: the drug I have swallowed or the sun shining through the window?

 

 

As a child you may have enjoyed Jerome K. Jerome’s novel “Three Men in a Boat”. If so, you probably remember J, the narrator, who after reading a patent medicine advertisement, discovered to his amazement, that he was a subject of all the diseases except housemaid’s knee. Since that time nothing has changed much, except more opportunities for self-checking are available via Internet and numerous apps. But the results are still confusing.  Suddenly you realize that multiple diseases are hunting you.

ThreeManinaBoat2

Are people confused because of the lack of the basic medical knowledge hidden beneath a sophisticated terminology? Partially so. Another part is the obscurity of medical terminology itself. Ideally, a scientific, in particular, a medical term is a denomination that has a precise and fixed meaning, at least for a certain period of time. In “hard” sciences such as, e.g., physics, chemistry or even mathematics, terms are mostly of operational character i.e. they are based on measurable facts verified in multiple experiments. Think about such seemingly abstract notions as mass, weight, gravity, motion, etc. that all have a precise and specific meaning.

Contrary to that, medical terminology was traditionally based on the set of observations vaguely described by a patient and subjectively interpreted by a physician. With the development of modern medical technologies such as ECG (electrocardiogram), EEG (electroencephalogram), PET/CT (Positron Emission Tomography – Computer Tomography, etc. and with the advance of sensor-based devices able to register concrete biological and clinical expressions of the human organism, medicine drifted closer to science, but its terminology has largely remained the same, dwelling on old principles of opinions and intuition.

Unlike in natural sciences, the sheer number of available synonyms in medicine describing deviations from the state of health and labeled as diseases, ailments, pathologies, disorders, dysfunctions, disabilities, anomalies and so forth already implies diagnostic uncertainty and the possibility for misconceptions. To a great extent, medical terminology reflects not the cause, but the overt symptoms of the disease.

Take, for example, such a widely used diagnosis as “angina pectoris”. Sounds scientific and impressive, but a mere translation from Latin would be “a strangling feeling in the chest”. The American Heart Association defines angina pectoris as “the medical term for chest pain or discomfort due to coronary heart disease”. If angina is a coronary diagnosis in itself, how can it be defined through other coronary heart disease? The description of the so-called disease is described through an ensemble of external equally confusing conditions: pain in your arms, neck, jaw, shoulder or back accompanying chest pain, nausea, fatigue, shortness of breath, sweating, dizziness. One can easily confuse such warning signs with a mere tiredness, exhaustion caused by stress or lack of sleep. Women with high level of tolerance are especially failing to recognize the approaching heart attack. One in four women in the UK dies through heart disease according to the British Cardiac Patient Association   being unable to identify the upcoming risk of cardio failure.

The situation is even worse in the area of psychology. For example, the whole bunch of notions related to autism is defined by Centers of Disease Control and Prevention (CDC) through rather subjective notions such as “disabilities that can cause significant social, communication and behavioral challenges”. The definition implies that there are certain stable social or behavior norms, deviations from which are branded as diseases. Often patients declared as autistic are treated with serious medications such as selective serotonin reuptake inhibitors (SSRIs) including citalopram, fluoxetine  and sertraline. According to Autism Spectrum Disorders Health Center ”it is widely believed (!) that elevation of these chemicals is associated with improvement in mood in depressed people”. Thus the modern psychology is relying on its widely spread beliefs prescribing treatments that may cause quite unpleasant side effects such as nausea, restlessness, insomnia, headache, weight gain or loss, sexual disorders, etc. Autism, attention deficit disorder (ADD) and bipolar syndrome (formerly known as manic-depressive disorder) are common psychological disorders that are misdiagnosed because of their loosely described expressions.

MedicalTerminlogy

The victims of ambiguity are, of course, patients. After going through numerous symptom checkers they, similar to J, suddenly realize that they are under attack of the array of diseases.  For example, the abdominal pain could be a symptom of a harmless indigestion with constipation as well as the sign of endometriosis, acute poisoning, ulcer or appendicitis.

No wonder that patients are not satisfied with the numerous symptom checkers available online or as mobile applications. Thus Harvard Medical School  research has tested  23 online “symptom checkers” run by brand names such as the Mayo Clinic, the American Academy of Pediatrics and WebMD, as well as lesser-knowns such as Symptomate. The study reflected the deep dissatisfaction of consumers. It reveals that as a whole all programs were astonishingly inaccurate. Symptom checkers provided the correct diagnosis in only 34 percent of cases, and within the first three diagnoses 51 percent of the time. One can hardly blame the software. It just reflects the traditional ambiguity of medical terminology based on non-measurable external manifestations of the disease.

Let us start with the basic – the pain. It is one of the most important indicators of the anomaly and one of the most challenging parameters for doctors to measure. Most of us were probably asked by a doctor to measure our pain from 1 to 8 (or 10 which is even more difficult). Beside the fact that people have different barriers of pain tolerance, it is not easy for an individual to spot the difference between, e.g., 6 or 7 pain levels.

smartcap_capred1But this can change. The new sensor-based technologies can provide more clarity on our body screams. Thus an Israeli biomed startup Medasence has developed a technology that mathematically measures pain in order to give doctors the best assessments. The pain monitor is a sensor-woven sleeve worn on a patient’s finger, which takes blood pressure, pulse, sweat, temperature and movement readings, using statistical tools to give an objective pain reading – noninvasively i.e. without disturbing a patient. Most important, it is measuring your own individual pain, not the statistical one.

Another vague symptom often discussed with your physician is fatigue. Fatigue could be a sign of severe disorders, but also a transitory mild violation, e.g., a consequence of the life style, workload or other routine activities. What is the difference between a normal fatigue level and the one we perceive as exhaustion? The Australian company EdanSafe has developed a Smart Cap, a fatigue monitoring system which can measure your electroencephalography or EEG by capturing your brain waves and  detecting Alpha (8 Hz to 13 Hz), Beta (>13 Hz to 30 Hz), Gamma (from 30 Hz to >100Hz), Delta (up to 4 Hz), Theta (4 Hz to 8 Hz), and Mu (8Hz to 13Hz) each of them reflecting the specific type of the brain activity.

One day smart sensors and nanochips may be getting into the most sacred area of our body – the brain, thus breaching the strongest bastions of medical ambiguity – the psychology.  Researches from MIT are  experimenting with flexible electronic device which can be delivered into the brain via injection. By deciphering the patterns of electronic signals produced by neurons those brain nanochips may shed light on the brain’s dysfunctions, such as schizophrenia or Parkinson’s disease, gradually transforming psychology from a philosophical speculations into an objective science.

Will medical terminology adjust to new objective methods in healthcare in order to be more precise and understandable for patients and consumers? After all, medical terminology is also a living language. As we move to the patient-centric care, it is important that patients and physicians should clearly understand each other. As said: in the beginning was the Word.

Our family friend called us after being discharged from a hospital. Since it was not the first time he got into the clinic we have asked what was wrong with him. ‘No idea,’ he replied proudly. ‘I specialize in history, not in medicine. Let doctors do their job’. He died shortly after in his lonely apartment not really knowing why. How could  an intelligent and educated person, the author of several books on American history, be so obstinately ignorant about his own health? In fact he did not even “own” it. He “delegated” his health matters to others he considered to be more knowledgeable and therefore responsible for mundane medical realities.

An acquainted physician once told me: people are ready to surf over the Internet to check on their health , but in case of a real pain they turn to the doctor. In desperation you are often tempted to believe in magic, with a doctor assuming the role of a magician.

The statement reminded me of the US psychiatrist Eric Berne  who had examined human interactions, or “transactions”, between a given person and other people. He distinguished three basic levels of personality manifested in human behavior: “parent”, “adult” and “child” and accordingly six (3´2) patterns of interpersonal communication, three main of them are: “adult-adult”, when people communicate on the same level of equality and reciprocal respect, acting in mutual interests; “parent – adult”, when one with the assumed authority provides comprehensive guidance to another and, finally, “parent – child” when the latter is submissively receiving orders from the allegedly authoritative person perceived as strong and senior.

PatientFearDoctors

One can extend this approach to healthcare. If you are in a hospital it is easy to spot three typical models of doctor-patient interactions: physician treats a completely obedient patient (parent –child); patient consciously follows the doctor’s instructions (parent – adult); and mutual cooperation, in which the physician negotiates a therapy plan with the patient (adult – adult).

Some of the studies indicate that the second (parent – adult) model is the most commonly used [1].

Today, patients are encouraged to change their behavior to be active partners to physicians, and the latter have to accept it. After all,  less active patients bear 21 percent higher costs than the active ones![2].

But are both parties ready? Mutual cooperation requires a big cultural change equally from patients and medical professionals. The perception that a “sick person is not responsible for their conditions and thus should be exempt from normal social roles” is historically rooted in the European mentality. The concept of the “universal sick role” created by American sociologist, Talcott Parsons postulates that a sick person should try to get well and seek a professional medical assistance, because she/he is incompetent to help himself.

One subject often found in studies of dependence is that the latter results in behavior which is beneficial for the party dependent upon i.e. in our case for the medical professionals and in many doctor-patient interactions is expected to lead to a priori, pre-emptive obedience. Let us also not forget, that a physician has an initial advantage compared to the patient. A hospital for a physician is a familiar working environment with the rules he/she is accustomed to. For a patient the whole situation getting to the hospital is a collapse of his everyday life.  He is overwhelmed by fears, doubts and uncertainties on top of that forced to endure unpleasant, often humiliating procedures.

The challenge starts with the mentality. We have to accept the fact that physicians and patients think differently. For a physician, especially in a large hospital, a patient is one of many. He has to go through multiple approved clinical procedures that are believed to work for many, but not necessarily for everybody. Patients have only one interest: to be healed. Each patient perceives himself as a unique entity and expects to be treated accordingly.

The next challenge is communication. Clinicians tend to presuppose that individuals understand, although not fully, their health issues. However, quite often patients are cautious to ask for clarifications, e.g., out of fear to look stupid or to irritate their doctors. This could drive misperceptions for both patients and clinicians. In a survey conducted by McKinsey, 76 percent of the participants with high-risk clinical conditions  nevertheless described themselves as being in excellent, very good, or good health. Maybe some of them  were misled by the desire to escape from the hospital as soon as possible!

DoctorPatinetCommunication

Every hospital’s instructions postulate that a patient has the right to receive information in a form she/he understands. Doctors are suggested to ask polite questions in non-dominant tone such as “what do you think?” to verify patient’s understanding of the information received. But reality is often different. Lack of time, fatigue and frequent indifference do not allow physicians to spend as much time with a patient as needed.

There are still many examples when physicians instinctively do not want to brief patients with the required level of clarity while perceiving an intelligent, knowledgeable patient as a threat to their authority. Once I was observing a patient with a cardio failure who was curious about his ECG results. ‘You have to study for 6 years to understand it anyway,’ dropped the cardiologists. A patient, apparently a person with the university degree, remained silent. Yes, he did not study medicine, but for sure he was  capable to understand the interpretation of standard cardiographic signals.

Often patients who demand attention and clarifications are branded as “difficult”. Special “guidances” are designed to deal with them. Thus the Nursing Link provides some interesting suggestions. For instance, the instruction  standard rule states that a patient can approach the nurse only between definite hours and only at the nursing station. That should ensure that “patients don’t take the free for all approach.”

As patients we still need to learn how to establish active partnership with physicians to combat malpractices of our healthcare system. One can start with:

PatientEducation

 Self -education. You may not get the same level of medical competence as your doctor, but you can understand your own illness. There is an abundance of knowledge scattered over the Web! Professional resources such as NHS Choices , Patient Care and Health Information from Mayo clinic  or  UpToDate Subscriptions for Patients and Caregivers could be helpful.

Use social network. There may be millions not exactly like you, but still going through similar experience. Think about online communities such as PatientsLikeMe or Ask a Patient or Health Treatment Web site to connect to these people.

Understand your rights. There is Patient’s Rights codex that every country has to respect. It is true that the knowledge of your rights does not always guarantee their implementation, since you are not always sure whom to complain to. Thus in Germany you can go to the chief medical doctor or write letters to a variety of medical authorities, but beware that all medical administrations will be against you, so prepare yourself for the court. It maybe easier in countries like Sweden. A patient can go to her/his municipality and complain to the person there responsible for the Patient Rights. There are Patients Associations in almost every country such as Patient Association UK or International Alliance of Patients Organizations  that are not always vocal, but still could be of use.

Prepare yourself for a conversation with your doctor. You do not have much time for one to one with your physician. So prepare your questions in advance based on the knowledge you have already acquired. Good if you could track your own health data or vital signs. Even if your physician does not trust such “personal data”, she/he still may look at the graphs. There are number of free apps to track your blood pressure, glucose level or heart rate. Online platforms like Health Vault or Health Kit will help you to accumulate the data and share information with your  physician.

 Stop feeling yourself small. Remember that hospitals and healthcare are not for physicians, it is for patients i.e. for you. People who have courage to demand their rights are often getting better services, compared to those who meekly accept what is given. A reluctantly disclosed secret from NHS is that “patients who complain get better care”.
patient%20cartoon

New technologies like smartphones and tablets allow people to get a better control and understanding of their health conditions. But, finally, it is our own determination and choice if we want to do it or grant this role to someone who claims to be professional but can be indifferent to us as a person.

As a patient and individual you deserve care and respect. Respect often is not  given for  granted. So rephrasing a famous poet, be not  like “a driven cattle, be a hero in the strife” !

References:

  1. Szasz T, Hollender M. A contribution to the philosophy of medicine: the basic models of the doctor-patient relationship. Arch. Intern. Med., 1956; 97:585-92.
  2. Commonwealth study

Smart pills with sensors as well as miniature implants placed, e.g., under the skin are predicted to grasp minds and souls of the consumers cramping fitness devices like wrist bands or watches. Thus, the “Smart Pills Technologies Market (2012-2017),”  report forecasts the global smart pills market to reach $965 million by the year 2017, while Gartner expects shipments in the smart garment category to jump from 0.1 million units in 2014 to 26 million units in 2016.

The grid of miniature interconnected devices, mostly sensors that can be wearable or implantable (known as a body area network (BAN), can radically transform the mainstream of Healthcare. Registering multiple parameters such as body temperature, perspiration, electrical conductivity of the skin or electric field distribution around the body, the Internet of Health (IoH) can provide data which, if properly interpreted, would track multiple disorders of the organism’s subsystems casting a deeper insight into the origin of diseases such as diabetes or cancer.

What disruptive changes can IoH bring to our Health system, in particular, to consumers and patients?

  • Transition to Holistic health.

For centuries, medicine has been collecting physiological facts to describe various human organs with limited understanding of their interplay, the approach often leading to misdiagnosis and medical errors. The IoH technologies are expected to overcome such pitfalls. This topic discussed by respectable scientists at the 2015 BIO International Convention in Philadelphia. Thus Donald Jones, the chief executive officer of Trial Fusion, argued that gadgets should be viewed as “nodes on the net” or transmission hubs emitting important information from different sources to help researchers form a more comprehensive picture of a person’s illness.

BrainSixthSence

It is curious that some successful endeavors are already springing not from medical, but e.g. automotive industries. All of us are used to a quick car sanity check before we start the trip. Multiple sensors are “calling” different parts of the machine to inspect its health. Why not to check the driver? The Sixth Sense by Jaguar/Land Rover attempts to monitor a driver’s fatigue or lack of concentration by combining multiple measurements such as heart rate, respiration and brain activity collected through sensors embedded in the steering wheel. Other automotive manufactures like Ford, Toyota or General Motors are taking the same direction.

The indigestible sensors will revolutionize diagnostics by monitoring health status noninvasively under natural conditions.  A tiny pill travelling through the human body interacting with saliva, blood, urine and/or gastric juices will be collecting data to provide a multidimensional view of the human organism. The information is wirelessly transmitted to physicians to identify early deviations from the individual’s health stability.

Scientists from the Weizmann Institute Israel are having an ambitious goal to develop   “lab-on-the molecular”, a combination of fluorescent molecular sensors  that integrate the properties of molecular luminescent sensors and cross-reactive sensor arrays (the so-called chemical ‘noses/tongues’). On the one hand, molecular sensors can differentiate between a wide range of analyte combinations and concentrations; on the other hand, they can operate in the microscopic world, which macroscopic analytical devices cannot access. Responding to the slightest chemical modifications of the molecular complexes in the organism such sensors are able to operate as “smart diagnostic devices”, kind of molecular spies. Suitable platforms for luminescent sensors are nanoobjects, in particular, semiconductor or noble metal quantum dots that can interface with molecular complexes in the living organism.

 

  • Noninvasive diagnostics

The mainstream of medical diagnostics methods tends to interfere with the human body, often stretching organism to the extremes thus pushing it out of its stability margins. For example, the ubiquitous exercise-electrocardiogram (stress ECG or cardiac stress treadmills) so favored by the doctors can be detrimental for the patients, in some cases leading to aortic stenosis and heart attacks as well as contingently causing nausea, high blood pressure or chest pain/angina pectoris. (Myocardial infarction in approximately 1:5000 tests and death in about 1:10 000 tests, Freedman B. Cardiac Society of Australia and New Zealand. Safety and performance guidelines for clinical exercise stress testing. 2010, http://www.csanz.edu.au.) .

Erik Topol, chief academic officer Scripps Health (San Diego) and one of the strongest proponents of the consumer oriented nanotechnology is working with Axel Scherer, PhD, of Caltech on tiny blood stream nano sensor chips that might spot predecessors of a heart attack. The sensors are picking up a specific genomic signal coming from endothelial cells that are sloughed off an artery wall in a precursory period before a heart attack. By transmitting the alert via smartphone to the cardiologist the myocardial infarction potentially can be prevented.

SmartGarmet

Personal wearable sensor garments can soon become a fashion.

This HealthWatch , 15-lead ECG-sensing T-shirt can read heart rate, blood pressure, detect cardiac irregularities and other vital signs that can be the key to preventing heart attacks. Data is generated in real time and reaches doctors immediately. The design is quite practical: one can throw this T-shirt in the laundry with the rest of your clothes. Cardiologists can observe their patients remotely, without hooking them up to a heart-measuring device in doctor’s office.

Endoscopy or colonoscopy can be a nightmare for patients suffering from gastroenterological illnesses such as, e.g., Crohn’s disease or ulcerative colitis.  The inflammation can be located in the small intestine that doctors can barely see. A tiny camera size of a vitamin pill such as used in the Beth Israel Hospital in New York City is travelling through the guts taking pictures every few seconds and transmitting them to a device on a patient’s belt.

Recently the Technion-Israel Institute of Technology together with Alpha Szenszor, the Boston-based manufacturer of carbon nanotube sensing equipment, announced the commercial version of Na nose, the device that has been proven in numerous international clinical trials to differentiate between various types and classifications of cancer with up to 95 percent accuracy. Patients breathe into a tube; the Na-Nose analyzes more than 1,000 different gases that are contained in the breath to identify those that may indicate potential disorders.  Normally patients with suspected lung cancer have to go through a CT scan when they feel the first symptoms. That maybe too late.  Cumbersome and invasive biopsies of tumors can disturb malignant cells and provoke their further spreading. The introduction of nanosensor technology to medical practices allows spotting the location of suspected cancer at a very early stage. The whole procedure is much cheaper and hence more affordable.

  • Personalization of Healthcare.

The traditional European healthcare was regarding a patient is a statistical unit. The conclusion that followed was “what is good for the majority will work for a given individual”. This principle is the foundation of the contemporary pharmaceutical industry. Millions of people are prescribed the same medications with the strong requirements to comply with “what the doctor tells them”. The attempt to understand how medication impacts a given individual was largely neglected. The result is that 50% of patients are not taking their medications as prescribed. Almost all medications aimed at treating people with long term chronic conditions have severe side effects that are revealed gradually with the substance accumulation in the body. The human metabolic systems vary from person to person and hence differently absorb medications into the bloodstream. In some cases a drug dosing may be too sudden and too much active ingredients enter the narrow absorption window; in other cases, an insufficient amount of drug is absorbed and the active ingredients get quickly flushed outside the body. Considering that people over 65 are taking five or more prescriptions, the threat of drug interactions, negative side effects or overdose is quite acute. Moreover, most medications can be poisonous unless taken in proper doses.

Accordion Pill

The Israeli company Intec  has designed an oral drug delivery system, the Accordion Pill  that looks like an ordinary-sized capsule but once inside the stomach it unfolds like an accordion to monitor the absorption of the swallowed drugs. The pill can be programmed to retain the acting pharmaceutical ingredients in the stomach for as long as 24 hours, so instead of taking 5 pills a day one can administer the medication only once.

Another good example of a digestible microchip was designed by a company called Proteus.  When swallowed, the chip with embedded sensors generates the “slight voltage in response to digestive juices,” which sends a signal to the surface of the patient’s skin. An attached patch catches the signal and transmits information to a doctor’s mobile phone. A device can also monitor patient’s heart rate, respiration and temperature informing the physician on how this particular patient is responding to medications. The point is that the doctor can adjust the treatment to the particular patient vs. forcing him to comply blindly with what “is normally believed to work”.

 

Conclusion:

The Internet of Health, the network of wearable or implanted sensors is disrupting the fundamental principles of traditional medical methodology such as treating disease vs. sustaining health, addressing anonymous patients vs. individuals, relying on intuition vs. measurable facts.

For the first time a patient has a chance to be treated as a human being vs. a collection of organs and receive care without going through torturous procedures that in some cases can be devastating for health.

The IoH might generate the new flow of applications and portable devices capable of addressing vital health issue helping people to understand and measure their everyday health conditions. The market of current Health and Fitness devices designed merely for strong and healthy has to give way to the one of new technologies dedicated for those who need it most.

 

Despite the long history of medical scholarship and research, the answer is still not straightforward. Science is based on measurable facts verified in multiple experiments. Moreover, scientific facts hold universally. For example, gravitation, conservation laws or Newton’s law of inertia work everywhere in the Universe. Therefore scientific results could be regarded as objective.

Massachusetts, USA --- Doctor Peering into Crystal Ball While Patient Waits --- Image by © Cary Wolinsky/Aurora Photos/Corbis

Art, on the contrary, relies on intuition and inspiration and is intimately connected to its creator. Therefore it has a local value and is subjective by nature.  Between those two extremes oscillates medicine.

Contrary to positive sciences such as physics, chemistry or biology, the ambivalent status of medicine is dwelling on three major misconceptions, often preventing objective diagnostics and effective therapy.

 

 

Total is a sum of its parts.

For centuries, medicine was collecting individual physiological facts trying to describe various human organs, with limited attempts to understand their interplay.

Contrary to its oriental sisters such as Chinese or Indian medical techniques (e.g., TCM and Ayurveda) that assumed the universal interconnectedness within a person, among people, their health, and the Universe, the Western medicine believed that after “fixing” the injured subsystem with a prescribed treatment or medications the whole organism would return to its equilibrium. The entire homeostatic system of human body was dissected by the mainstream of European medicine into various diseases. This approach  is now reflected by a set of diverse medical specialties such as gastroenterology, cardiology, psychiatry, etc. The knowledge in each of the specialties was mostly evolving within itself – deep, but narrow.

This approach has a fundamental deficiency well known in other natural sciences, e.g., in physics of complex systems (and human body is a complex system): the sum of parts does not constitute the whole.

Body as its parts

Health is a holistic notion. There is no such thing as a partial health. The human organism can be regarded as a complex open system in a state of delicate equilibrium exchanging chemical substances, energy and entropy (information) with the outer world. Since the whole organism consists of a number of strongly coupled and cohesively working subsystems, the failure of any one of them tends to provoke an avalanche of other failures. Therefore, separate treatment of a single organ, disregarding impact of a disease on other subsystems or recklessly administering strong locally acting medications, may result in complications involving other organs.

This “focused” approach in medicine also leads to ignoring side effects. Take for example the wide-spread medication known as Bisoprolol, a readily prescribed beta-blocker to treat hypertension. It reduces the activity of the heart by blocking tiny areas (called beta-adrenergic receptors) where the messages are received by the heart muscle. But for patients, suffering from cardio problems, often associated with hypertension, this medication can provoke a shortage of breath and a cardiac rhythm disturbance, most frequently dangerous arrhythmia or bradycardia (especially when prescribed together with calcium channel blockers).

Many experienced physicians innately acknowledge the deficiencies of such fragmented knowledge, attempting to compensate them with intuition, rather than relying on prescribed guidance that can be based on the same erroneous assumption of compartmentalization. Quoting Dr. Jeffrey Braithwaite, Foundation Director, Australian Institute of Health Innovation: “slavish adherence to increasingly voluminous and often piecemeal guidelines is an obstacle to flexible, intuitive, effective care” [1].

The European medicine, unlike science, has drifted toward a technique of intuitive feature extractions and subjective judgements called “Art” when successful, and when not, then paving the way towards false diagnostics and medical errors.

  • Individual equals statistical unit.

Clinical protocols and medical guidance adopted by European medicine mostly rely on averaged statistical data i.e. individual characteristics are largely neglected (being habitually labeled as “unspecific“). This method is fundamentally wrong since it is based on an implicit assumption of the Gauss distribution underlying medical statistics. Yet the statistics of emergent diseases, similarly to heavy accident statistics, seem to obey power law distributions rather than exponential ones. Note that statistical results, e.g. produced in clinical trials, in fact do not answer the crucial question: what is the best strategy for a specific individual.

Therefore the whole concept of “evidence-based medicine” which is actually based not on evidence, but on statistical simplifications does not suggest what is good for a given patient. The fact acknowledged by a number of physicians.

Medical science is applying statistical approach to models assuming their complete symmetry (i.e. that the models are basically the same), but in reality medicine is using statistics in regard to humans that are different by default. Therefore relying on statistical methods in individual medical cases is not always correct. The consequence is that many medical techniques can be more harmful than beneficial for patients.

Take for example the “sugar curve”, which is a colloquial name for a glucose tolerance curve (whose linear part is usually known as a dynamic range). Such a test nominally requiring the glucose intake not exceeding 125 g (who really controls it?) but can be indiscriminately administered, e.g., to the patients already having diabetic ketoacidosis. The beginning of adverse effects such as vertigo, blurred vision or even fainting occurs not rarely and marks the diabetic health boundary, in extreme cases leading to coma.

Another example is the ubiquitous exercise-electrocardiogram (stress ECG or cardiac stress treadmills) which is favored by the doctors but can be contingently detrimental for patients, e.g., suffering from hypertension. One patient complained that his blood pressure during ECG stress test raised up to 285 systolic and 190 diastolic. Nevertheless, his cardiologist proceeded with the test, since a patient did not complain of the chest pain, a symptom obviously more important for a cardiological test than a  blood  pressure (AD).

  • Focus on disease vs. health

Although the notions “health” and “medicine” are commonly used interchangeably in various contexts, there is a crucial difference between them. Medicine deals with deviations from healthy conditions and treats diseases mostly by medications, surgery and, since comparatively recent times, by laser and ionizing radiation. The very term “medicine” stems from the ancient “art of healing” i.e. returning to health. It is not accidentally that the object of treatment in medicine is known as “patient” whereas health can (and should) be maintained in any person.

'Don't worry. We still have a few more treatment options available.'

People feel themselves healthy as long as their organisms are capable to maintain stability under an influx of external real-life influences such as stress, psychic overload, microorganisms, fungi, allergens, etc. Contrary to the dominant – and unverifiable – presumption that diseases mainly arise from erroneous behavior or unreliable functioning of individual body organs, partly genetically determined, the idea of a holistic health leads to the concept that diseases are rooted in the very foundation of the complexity of a human organism that involves numerous interconnected components and subsystems. The possibility of a disease may not spring from the failure of a distinct body part (organ), although it can be manifested as such, but can be the property of the whole organism. Hence radical treatment of a single organ can have a overall negative effect, driving health of its stability margins.

The deficiencies of a fragmented approach to treating health is most vividly demonstrated in case of complex disabilities such as, e.g., chronic fatigue syndrome, or CFS when a person feels so tired that he/she is unable to complete normal daily activities. The CHF Health Center recognizes that “the fatigue syndrome has no known cause and is difficult to diagnose”. So the therapy decides to focus on “the major symptoms” that allegedly “can be treated”.

But how can one treat symptoms leaving aside the cause and even unable to properly diagnose the disease? Instead of bringing a patient back to healthy conditions, the therapy relies on a variety of medications such as antidepressants that are purposefully changing the balance of brain chemicals (neurotransmitters). Although it is generally stated that antidepressants have no severe side effects, such frequently prescribed medications as adapin or doxepin can provoke pathological conditions such as orthostatic hypotension, tachycardia, ventricular arrhythmias and even lead to breast cancer.

The European medicine is gradually adopting the approach of “maintaining health of the healthy” and supporting natural resources of the organism to help it to return it to its stable conditions. For example the oncological immunotherapy with medications such as, e.g., Keytrouda (Pembrolizumab (formerly MK-3475 and Lambrolizumab) is focused on strengthening the body’s natural immune system impelling it to attack and destroy the cancerous cells, rather than trying to destroy the malignant tumor by means of dangerous chemical drugs that come with serious side effects.

 

 Conclusion:

With no intention to diminish the achievements of the contemporary medicine, one has to accept that it is lagging behind positivistic sciences in understanding human organism as a cohesive complex system with tight interplay of its related parts.

 The mainstream of physicians are still treating a disease vs. treating a patient to maintain her/his health. This approach often leads to wrong diagnostics, medical errors and serious side effects that endanger patients.

True there are a lot of achievements performed with the help of modern medical (in fact physical) technologies such as X-rays, CT, MRI, PET screening, pulsed lasers, proton therapy or other advanced procedures. But the majority of such technologies should be applied carefully and by thoroughly trained staff since they are still based on invasive methods that disturb health and can be harmful for a patient.

“Great expectations” are connected with the development of sophisticated body sensors designed to convert the body physiological characteristics such as pulse rate, blood pressure, ECG (electrocardiogram), EEG (electroencephalogram),) PPG (photoplethysmogram), ENG (electronystagmogram) and EMG (electromyogram) signals, local thermal (infrared) emission, skin wetness, etc. into sequences of electric pulses and further into digital signals that can be processed by some central unit, at present by a computer or a smartphone. By collecting biological feedbacks from an individual organism in a noninvasive way, body sensors may help physicians to transit from the illusive intuitive descriptions of arbitrary selected symptoms, to objective and measurable manifestations of a health status.

The physicians of the future will require a new type of education which will help to overcome traditional pitfalls of medicine. The new type of medical knowledge will encompass multiple areas of natural sciences such as physics, chemistry, and biology to address the fundamental laws of the human organism viewed as a complex biological system (a metabolic reactor) rather than adhering to fragmented clinical methods. We see the emergence of such a converged knowledge already with the development of new branches of science such as, e.g., bioengineering, bioinformatics, computational biology, etc. that are already opening new opportunities for medicine and healthcare. Until this knowledge fusion fully happens medicine, according to William Olser, one of the founding professors of Johns Hopkins Hospital, will remain “the science of uncertainty and the art of probability”.

  1. https://healthmanagement.org/c/healthmanagement/issuearticle/guest-editorial-3?utm_source=Newsletter&utm_medium=Email&utm_campaign=Content
  2. http://www.cdc.gov/ncbddd/autism/index.html
  3. http://www.bcpa.co.uk/factsheets/Angina.htm

Continuity of medical services and accessibility of care are hallmarks of a successful healthcare system. Unfortunately this vision is not always attainable for a professional rehabilitation considering its habitually high costs. Specifically, if we talk about multiple intuitively demarcated deficiencies such as, e.g., Mild Cognitive Impairment (MCI), which is loosely defined by Mayo Clinic  as an “intermediate stage between the expected cognitive decline of normal aging and the more serious decline of dementia”.

Is MCI really a disease or is it a signature of a normal aging process, perhaps aggravated by some bad  life habits, e.g., smoking, alcohol or lack of physical exercise? Considering some of the alleged MCI symptoms [1] such as “forgetting things more often” or “losing your train of thought or the thread of conversations, books or movies” (which may very well happen to a young person when one stares at the TV screen with a glass of wine after a long and stressful day) many of us could be on the way to MCI if not already there. Can we better understand the real causes and possibly prevent cognitive deteriorations such as MCI, dementia or Alzheimer’s disease (AD)?

Recalling the rapid population aging, especially in the developed countries which, according to WHO, will reach by 2050 approximately 2 billion people aged over 60 thus accounting for 22% of world’s population, the preventive measures against MCI will be crucial for the world social and economic stability. We should start exercising our brain, just as we are getting used to keep our bodies fit.

How can we train something so intangible as Mind and Soul in a way that every person can easily afford it?

To address this challenge the Spanish group of medical researchers and IT experts designed NeuroAtHome, a virtual rehabilitation platform for people diagnosed with Mild Cognitive Impairment. The system includes more than 100 rehabilitation tasks destined to treat specific motor or cognitive functions.NeuroatHOMEMCI2An individual is offered a set of cognitive and physical 3D videogame exercises tailored to his/her capacities and needs. A natural user interface allows one to work on the task distantly with hands’ gestures (or even eye movements), so that a physician can check both cognitive status and the precision of the motoric.  The complexities of the task corresponds to the Global Deterioration Scale (GDS), developed by Dr. Barry Reisberg that provides an overview of the stages of cognitive function for those suffering from a primary degenerative dementia.

Each rehabilitation task performed by a patient is quantified: Neuro@Home Pro measures the number of successfully completed tasks, response time and total number of completed tasks. The rehabilitation team can evaluate the progress not only by observations, but by “measurable” facts. New rehabilitation tasks may be added, existing ones modified or the program can be entirely stopped if not considered useful anymore. In a word: the therapy can be personalized and adjusted to the individual needs of a patient.

NeurAtHomePNG.PNGExamplesOne part of NeuroAtHome is installed in an individual’s home, another one in a clinic. A physician can monitor his patient remotely from any location (e.g., from the hospital or physician’s house), while patients can definitely cut on long distance travelling.The system is utilizing Microsoft Kinect sensors such as IR Emitter and IR depth sensor for capturing body motions, including facial contractions, and to create digital skeleton. Tilt sensors are calculating the correct angle and position of the body while color sensors detect the slightest fluctuations in the skin color such as emerging paleness or redness.   As blood passes the vessels, Kinect camera recognizes the variations of the facial color intensity to establish how fast the blood is pumping. This helps the physician to objectively detect the level of the stress a patient experiences from exercises and to adjust the program.NeuroAtHomeMCI

The results of the performance are stowed in Microsoft Cloud Azure platform for further analysis. Physical data are collected and stored into patient’s profile by Kinect, so the next time one reaches the system it recognizes its user.With NeuroAtHome monthly subscription one can have an  access to multiple virtual training programs.

The overall rehabilitation is now considerably cheaper than the traditional treatments provided by  clinics where normally a patient is discharged not when she or he is fit, but when the insurance expects her/him to leave.

More and more clinics are looking for new ways to make the rehabilitation therapy more affordable to provide the high quality treatment  as long as individual requires.  One of such clinics is Hospital La Pedrera that has already treated 175 patients using the NeuroAtHome rehabilitation platform. When asked if they would like to continue the training, 99.4% of patients found the virtual therapy highly motivating. NeuroAtHome allowed patients to receive, on average, 30% more physical therapy sessions and 15% more cognitive therapy sessions using the same available resources. The increased efficiency resulted in improved patient outcomes: patients that used NeuroAtHome were discharged, on average, 3 days earlier.

During the first quarter of 2015, NeuroAtHome reached 4,000 patients delivering over 300,000 sessions, in both medical and home environment.

The spectrum of personalized training programs address multiple aspects of impairments: from muscular–skeleton, to brain and spinal cord injuries, from chronic and neurodegenerative conditions to active aging.

If the technology can capture and analyze practically unlimited number of individual cognitive sings for providing personalized therapy, could it now offer a more measurable insight into the nature of cognitive impairments? I believe it is the time one tries it.

Resources:

  1. http://www.alz.org/dementia/downloads/topicsheet_mci.pdf